| Introduction | List of E-Roads | Reaction |
| Country | City | Lat/Long | Km (section) | Km (cuml.) | Connection |
| D | Schweinfurt | 50° 03' N 10° 16' E | 0 | 0 | |
| D | Bayreuth | 49° 57' N 11° 35' E | 95 | 95 | E51 |
| D | Marktredwitz | 50° 00' N 12° 06' E | 37 | 132 | |
| CZ | Cheb | 50° 08' N 12° 28' E | 30 | 162 | |
| CZ | Karlovy Vary | 50° 13' N 12° 52' E | 30 | 192 | E49, E442 |
| CZ | Praha | 50° 06' N 14° 26' E | 112 | 304 | E50, E55, E65, E67, E59 |